The JAK-STAT pathway plays a central role in chronic inflammatory diseases, such as rheumatoid arthritis (RA).1,2
In RA, inflammation is the major contributor to disability in early disease; radiographic progression dominates disability later in the disease process.3
Dysregulation of immune response ignites the uncontrolled inflammation of RA, which is fuelled by excessive signalling via the JAK-STAT pathway.1,5
HCP, healthcare provider; JAK, Janus kinase; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription.
REFERENCES
1. Malemud CJ. Integr J Mol Med. 2017;18(3). Pii:E484. 2. Banerjee S, Biehl A, Gadina M, Hasni S, Schwartz DM. Drugs. 2017;77(5):521-546. 3. Emery P, McInnes IB, van Vollenhoven R, Kraan MC. Rheumatology (Oxford). 2008;47(4):392-398. 4. Kirwan JR. J Rheumatol. 1999;26(3):720-725. 5. Hodge JA, et al. Clin Exp Rheumatol. 2016;34(2):318-328. 6. McInnes IB, Liew FY. Nat Clin Pract Rheumatol. 2005;1(1):31-39.
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